The guy in the middle has a total knee replacement on one knee and has done very well from it…..14 years out…no problems…done by an expert joint replacement surgeon (not me). With the left knee, he failed to get symptom relief with medications and steroid shots (couple rounds) and viscosupplementation. He is now a golfer and ex pro baseball player and front row Lakers fan in this picture from the Staples Center last night. We decided to try PRP for his left knee and gets over 50% pain relief and stays off of all NSAIDs and narcotics for 6-7 months….then we redo the PRP. Leukoctye poor….PPP is filtered in an attempt to increase concentrations of the plasma proteins in the PPP…primary known targets are A2M and IRAP. For him PRP every 6-8 months is a better choice than a TKR….even with a great TKR on the right side!