This is an interesting application of orthobiologics for a wrist problem that often requires surgery. The patient had a chronic history of left wrist distal radio-ulnar joint instability that persisted despite 5 months of nonoperative treatment modalities. We discussed surgery and orthobiologics and because it would burn no bridges and potential be effective, a stem cell injection was agreed upon as the best choice for her at this time. We went thru a lengthy informed consent process and we all were satisfied with the potential risks and rewards. The in office procedure took 1 hour from start to finish. Her early recovery is promising…with some bruising but no recurrent subluxations so far.